Ginkgo Biloba and SSRIs (General): Interaction Overview
Ginkgo biloba has mild monoaminergic effects (weak serotonin and dopamine reuptake inhibition) and inhibits CYP2C9, an enzyme that metabolizes some SSRIs.
Mechanism of Interaction
Ginkgo biloba has mild monoaminergic effects (weak serotonin and dopamine reuptake inhibition) and inhibits CYP2C9, an enzyme that metabolizes some SSRIs. This could slightly increase SSRI plasma levels, potentially enhancing both therapeutic and side effects. The interaction is considered mild at typical supplement doses.
Recommendation
Combining is generally considered low-risk at standard doses (120–240mg standardized ginkgo extract). Start with lower doses and monitor for SSRI side effect amplification (nausea, insomnia, sexual dysfunction). Inform your prescribing physician.
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Ginkgo Biloba
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