Blood Thinners and Omega-3 (EPA/DHA): Interaction Overview
Omega-3 fatty acids (EPA and DHA) at doses above approximately 3g/day inhibit platelet aggregation by displacing arachidonic acid from platelet membranes, reducing thromboxane A2 production.
Mechanism of Interaction
Omega-3 fatty acids (EPA and DHA) at doses above approximately 3g/day inhibit platelet aggregation by displacing arachidonic acid from platelet membranes, reducing thromboxane A2 production. Combined with warfarin, aspirin, or novel anticoagulants, the bleeding risk is elevated. Standard supplemental doses (1–2g/day) are generally considered safe, but many physicians recommend stopping high-dose fish oil 1–2 weeks before surgery.
Recommendation
At 1–2g/day EPA+DHA: generally safe with standard anticoagulation. At higher doses (>3g/day), inform your prescribing physician and consider monitoring. Stop high-dose fish oil 1–2 weeks before any planned surgical procedure.
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Omega-3 (EPA/DHA)
Learn about Omega-3 (EPA/DHA)'s dosage, half-life, and other interactions.
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