Benzodiazepines and Melatonin: Interaction Overview
Melatonin promotes sleep via MT1 and MT2 receptor agonism in the suprachiasmatic nucleus.
Mechanism of Interaction
Melatonin promotes sleep via MT1 and MT2 receptor agonism in the suprachiasmatic nucleus. Benzodiazepines (and Z-drugs: zolpidem, eszopiclone) potentiate GABA-A, causing significant CNS depression. Combined, morning grogginess, impaired coordination, memory consolidation issues, and respiratory depression risk increase. This is particularly relevant for elderly users.
Recommendation
If using melatonin with a prescribed benzodiazepine or Z-drug, discuss with your doctor. Use minimum effective melatonin doses (0.5–1mg is often sufficient; many products contain 5–10mg, which is excessive). Avoid driving the morning after combining.
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