Ashwagandha and Benzodiazepines: Interaction Overview
Withanolides in ashwagandha (particularly withaferin A) bind to GABA-A receptors as positive allosteric modulators, similar to but weaker than benzodiazepines.
Mechanism of Interaction
Withanolides in ashwagandha (particularly withaferin A) bind to GABA-A receptors as positive allosteric modulators, similar to but weaker than benzodiazepines. Combining may produce additive CNS depression, excessive sedation, impaired coordination, and respiratory depression in extreme cases. The effect is dose-dependent and highly variable between individuals.
Recommendation
Use caution when combining. If on prescribed benzodiazepines, consult your doctor before adding ashwagandha. Start with low ashwagandha doses (150–300mg) and monitor for unusual drowsiness. Avoid driving or operating machinery until you know how the combination affects you.
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