Phosphatidylserine Half-Life & Clearance
Understand how long Phosphatidylserine stays in your bloodstream, its metabolic pathways, and how to time your doses optimally.
Standard Pharmacokinetics
Chart represents a single standard dose processed by a normal metabolizer over 24 hours.
Key Metrics
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Open Interactive CalculatorMetabolism & Excretion
Pathway
Incorporated into cell membranes; enzymatic deacylation in liver; slow turnover
Elimination
Feces primarily; slow lipid metabolism pathway
Important Nuances
PS integrates into cell membranes and has a functional lifetime much longer than its pharmacokinetic half-life. Cortisol-blunting effects are well-documented in stressed individuals. Once daily dosing is standard.
Frequently Asked Questions
When should I take phosphatidylserine?
PS is most commonly taken in the evening (100–300mg with dinner) due to its cortisol-reducing and sleep-quality-improving effects. Some users split the dose (morning + evening). Take with a fat-containing meal.
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